同轴静电喷射法制备载药纳米粒的研究进展

徐师,曹阳,周方晴,祁菲菲,张玲,许茜*

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (15) : 1285-1290.

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中国药学杂志 ›› 2014, Vol. 49 ›› Issue (15) : 1285-1290. DOI: 10.11669/cpj.2014.15.002
综述

同轴静电喷射法制备载药纳米粒的研究进展

  • 徐师,曹阳,周方晴,祁菲菲,张玲,许茜*
作者信息 +

Research Progress of the Preparation of Drug-Loaded Nanoparticles by Coaxial-Electrospraying

  • XU Shi, CAO Yang, ZHOU Fang-qing, QI Fei-fei, ZHANG Ling, XU Qian*
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摘要

目的 综述近年来通过同轴静电喷射技术制备载药纳米粒的研究进展,包括同轴静电喷射技术的基本原理,制备过程中的影响参数以及同轴静电喷核壳纳米粒的研究现状。方法 根据近年来国内外文献资料,总结、归纳已报道的关于同轴电喷制备纳米粒的相关研究。结果与结论 同轴静电喷射是一种简易的获得核壳纳米粒子的方法。利用这种技术能够将药物包封在聚合物纳米粒的内部,从而提高药物的包载效率,有效地减少药物的突释,保护药物的生物活性。通过选择不同的聚合物体系,调节同轴静电喷射的工艺参数,可以制备出具有理想核壳结构的纳米粒,同时也能有效地控制药物的释放速率和释放行为,从而设计制备出具有不同释药特性的递药系统。

Abstract

OBJECTIVE To introduce the basic mechanism of coaxial-electrospraying and influencing parameters of preparation process, and review the recent development of preparing core-shell nanoparticles by using coaxial-electrospraying.METHODS According to the recent literature data, the reported researches about preparation of nanoparticles by coaxial-electrospraing was summarized. RESULTS AND CONCLUSION Coaxial-electrospraying is a versatile method for preparing core-shell nanoparticles. Drugs can be encapsulated into the core of nanoparticles by using this technique, with increased loading efficiency and encapsulation rate, reduced burst release, and protected drug bioactivity. When different polymer systems are employed and coaxial-electrospraying parameters are readjusted, ideal core-shell nanoparticles can be prepared, and the release rate and release behavior can be effectively controlled, producing targeting-drug delivery system owing different release properties.

关键词

同轴静电喷射 / 核壳纳米粒 / 递药系统

Key words

coaxial-electrospraying / core-shell nanoparticle / drug delivery system

引用本文

导出引用
徐师,曹阳,周方晴,祁菲菲,张玲,许茜*. 同轴静电喷射法制备载药纳米粒的研究进展[J]. 中国药学杂志, 2014, 49(15): 1285-1290 https://doi.org/10.11669/cpj.2014.15.002
XU Shi, CAO Yang, ZHOU Fang-qing, QI Fei-fei, ZHANG Ling, XU Qian*. Research Progress of the Preparation of Drug-Loaded Nanoparticles by Coaxial-Electrospraying[J]. Chinese Pharmaceutical Journal, 2014, 49(15): 1285-1290 https://doi.org/10.11669/cpj.2014.15.002
中图分类号: R944   

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基金

江苏省自然科学基金资助项目(BK2010242)
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